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(1998) 13(Suppl

Potential issues and how to avoid them Combining potent actives requires awareness of possible problems

494,495 Both nickel and lower pH activate Hp NikR to bind to the ureA promoter with similar affinities and locations on the DNA, 495 but the mechanism of allosteric regulation of DNA binding by acidity remains unknown

The review also noted that GHK-Cus copper complexation ability raises Cu2+ penetration rates across the stratum corneum, and documented the development of formulation innovations including the TriHex peptide system that combine GHK-Cu-type tripeptides with hexapeptides to produce synergistic upregulation of regenerative genes and suppression of aberrant collagen deposition